Publications

Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-tumor activity of PD-1 blockade in melanoma.

Kim SH, Li M, Trousil S, Zhang Y, Pasca di Magliano M, Swanson KD, Zheng B. J Invest Dermatol. 2017


Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation. Zhang Q, Zhang Y, Parsels JD, Lohse I, Lawrence TS, Pasca di Magliano M, Sun Y, Morgan MA. Neoplasia. 2016 Nov;18(11):666-673. 


Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.

Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano MGut. 2017 Jan;66(1):124-136. 


Early pancreatic islet fate and maturation is controlled through RBP-Jκ.

Cras-Méneur C, Conlon M, Zhang Y, Pasca Di Magliano M, Bernal-Mizrachi E. Sci Rep. 2016 May 31;6:26874. 


Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages. Mathew M, Brannon AL, Del Vecchio ACD, Garcia PE, Penny MK, Kane KT, Vinta A, Buchanovich RJ, Pasca di Magliano M. Neoplasia 2016 Mar; 18(3):142-151.


GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer.

Waghray M, Yalamanchili M, Dziubinski M, Zeinali M, Erkkinen M, Yang H, Schradle KA, Urs S, Pasca Di Magliano M, Welling TH, Palmbos PL, Abel EV, Sahai V, Nagrath S, Wang L, Simeone DM. Cancer Discov. 2016 Aug;6(8):886-99.


Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation. Yang S, Imamura Y, Jenkins RW, Cañadas I, Kitajima S, Aref A, Brannon A, Oki E, Castoreno A, Zhu Z, Thai T, Reibel J, Qian Z, Ogino S, Wong KK, Baba H, Kimmelman AC, Pasca Di Magliano M, Barbie DA. Cancer Immunol Res. 2016 Jun;4(6):520-30.


Change isn't always better. Schofield H, Pasca di Magliano MElife. 2015 Aug 14;4. 


Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M.

Carcinogenesis. 2015;36(7):730-8.


ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis.

Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM. Genes Dev. 2015; 29(2):171-83.

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models. DeCant BT, Principe DR, Guerra C, Pasca di Magliano M, Grippo PJ. Front Physiol. 2014; 5:464.

Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis.

Thomas MM, Zhang Y, Mathew E, Kane KT, Maillard I, Pasca di Magliano M. BMC Cancer. 2014; 14:862.

Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signalingMathew E, Zhang Y, Holtz AM, Kane KT, Song JY, Allen BL, Pasca di Magliano M. Cancer Rep. 2014; 9(2):484-94.

Immune cells in pancreatic cancer: Joining the dark side. Zhang Y, McAllister F, Pasca di Magliano M. Oncoimmunology. 2014; 3:e29125. 
 

Kras as a key oncogene and therapeutic target in pancreatic cancer. Collins MA, Pasca di Magliano M. Front Physiol. 2014; 4:407. 
 

Roles for KRAS in pancreatic tumor development and progression. Pasca di Magliano M, Logsdon CD. Gastroenterology. 2013; 144(6):1220-9.
 

Deciphering the role of stroma in pancreatic cancer. Waghray M, Yalamanchili M, Pasca di Magliano MP, Simeone DM. Curr Opin Gastroenterol. 2013;29(5):537-43. 
 

Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidativeness reststance. Zhang Y, Yan W, Collins MA, Bednar F, Rakshit S, Zetter BR, Stanger BZ, Chung I, Rhim AD, Pasca di Magliano M. Cancer Res. 2013; 73(20):6359-74. 
 

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis. Zhang Y, Morris IV JP, Yan W, Schofield H, Gurney A, Simeone D, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Cancer Res. 2013; 73: 4909-4922.


    Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS-Induced Transformation. Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, Couch F, Wetmore C, Pasca di Magliano M, Fernandez-Zapico ME. J Biol Chem. 2013; Epub 2013 March 12. 
     

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice.
Collins MA, Brisset JC, Zhang Y, Bednar F, Pierre J, Heist KA, Galban CJ, Galban S, Pasca di Magliano M. PLoS One. 2012;7(12): e49707. 


Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. 

Collins MA, Bednar F, Zhang Y, Brisset JC, Galbán S, Galbán CJ, Rakshit S, Flannagan KS, Adsay NV, Pasca di Magliano M. J Clin Invest. 2012;122(2): 639-653 


c-Met is a marker of pancreatic cancer stem cells and therapeutic target.
Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M, Simeone DM. Gastroenterology. 2011 Dec; 141(6): 2218-2227 Epub 2011 Aug 22.

Pancreatic cancer and hedgehog pathway signaling: New Insights.
Dosch JS, Pasca di Magliano M, Simeone DM.
Pancreatology. 2010;10(2-3):151-7. 

New Frontiers in Pancreatic Cancer Research.
Khan GN, Pasca di Magliano M, Simeone DM.
Surg Oncol Clin N Am. 2010 Apr;19(2):431-51.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Decker T, Pasca di Magliano M, McManus S, Sun Q, Bonifer C, Tagoh H, Busslinger M. Immunity. 2009; 30(4):508-20. 

Common activation of canonical Wnt siganling in pancreatic adenocarcinoma.
Pasca di Magliano M, Biakin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, Sutherland RL, Dlugosz A, Rustgi AK, Hebrok M.
PLoS One. 2007 Nov 7;2(11):e1155.

A small-molecule antagonist of the hedgehog signalling pathway.
Lee J, Wu X, Pasca di Magliano M, Peters EC, Wang Y, Hong J, Hebrok M, Ding S, Cho CY, Schultz PG.
Chembiochem. 2007 Nov;8(16):1916-9. No abstract available.

Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M.
Genes Dev. 2006 Nov 15;20(22):3161-73.

Hedgehog signalling in cancer formation and maintenance.
Pasca di Magliano M, Hebrok M.
Nat Rev Cancer. 2003 Dec;3(12):903-11.Review. No abstract available.

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauers GY, Qi YP, Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M.
Nature. 2003 Oct 23;425(6960):851-6. Epub 2003 Sep 14.

The activation and maintenance of Pax2 expression at the mid-hidbrain boundary is controlled by separate enhancers. 
Pfeffer PL, Payer B, Reim G, di Magliano MP, Busslinger, M.
Development. 2002 Jan;129(2):307-18.

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